Flexeril and Linezolid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Linezolid (linezolid). Common drug interactions include thyroid neoplasm among females and anion gap increased among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Linezolid. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Linezolid?

Linezolid has active ingredients of linezolid. It is often used in infection. eHealthMe is studying from 21,891 Linezolid users. Check the latest studies of Linezolid.

On Jul, 16, 2026

11 people who take Flexeril and Linezolid together, and have interactions are studied.

Flexeril and Linezolid drug interactions.

What are the common drug interactions of Flexeril and Linezolid, by gender? *:

female:

Thyroid neoplasm (tumour of thyroid)
Weight decreased
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Depression
Anxiety
Arthralgia (joint pain)
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Renal impairment (severely reduced kidney function)

male:

Anion gap increased
Asthenia (weakness)
Obesity (having too much body fat)
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Perineal abscess
Pituitary-dependent cushing's syndrome (pituitary dependent hypercortisolism)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subcutaneous abscess
Type 2 diabetes mellitus

What are the common drug interactions of Flexeril and Linezolid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Anxiety
Arthralgia (joint pain)
Bone density decreased
Depression
Emotional distress
Fracture
Fractured sacrum
Gait disturbance
Hip fracture
Joint dislocation (a joint position is changed from normal position)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Depression
Emotional distress
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

50-59:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Drug resistance (reduction in effectiveness of a drug)
Emotional distress
Fracture
Hip fracture
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Anion gap increased
Asthenia (weakness)
Obesity (having too much body fat)
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Perineal abscess
Pituitary-dependent cushing's syndrome (pituitary dependent hypercortisolism)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subcutaneous abscess
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Hiv Infection: 3 people, 27.27%
Diabetes: 3 people, 27.27%
Weight Decreased: 2 people, 18.18%
Type 2 Diabetes: 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
K-Ras Gene Mutation: 2 people, 18.18%
Hypotension (abnormally low blood pressure): 2 people, 18.18%
Colorectal Cancer Stage Iv (cancer of colon and rectal spreads to liver or lung): 2 people, 18.18%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 1 person, 9.09%
Asthma: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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