Co-codamol and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Co-codamol (acetaminophen; codeine phosphate) and Morphine (morphine sulfate). Common drug interactions include drug exposure during pregnancy among females and vertigo among males.

The phase IV clinical study analyzes what interactions people have when they take Co-codamol and Morphine. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Co-codamol?

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 2,364 Co-codamol users. Check the latest studies of Co-codamol.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

60 people who take Co-codamol and Morphine together, and have interactions are studied.

Co-codamol and Morphine drug interactions.

What are the common drug interactions of Co-Codamol and Morphine, by gender? *:

female:

Drug exposure during pregnancy
Intra-uterine death
Nausea (feeling of having an urge to vomit)
Overdose
Platelet count decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Infection
Abdominal pain upper

male:

Vertigo
Deafness bilateral
Hypoacusis (loss of hearing)
Post procedural complication
Abdominal pain
Acute respiratory distress syndrome
Confusional state
Pain in jaw
Alanine aminotransferase increased
Blood alkaline phosphatase increased

What are the common drug interactions of Co-Codamol and Morphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level increased
Haemorrhage in pregnancy (bleeding in pregnancy)
Loss of consciousness
Maternal exposure during pregnancy (use of substance during pregnancy)
Pallor
Tremor (trembling or shaking movements in one or more parts of your body)
Uterine contractions
Nausea (feeling of having an urge to vomit)
Overdose

30-39:

Drug exposure during pregnancy
Intra-uterine death
Swelling face
Abortion spontaneous (naturally occurring miscarriage)
Drug ineffective

40-49:

Vertigo
Deafness bilateral
Drug level increased
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Deafness transitory (deafness temporary)
Hypoacusis (loss of hearing)
Post procedural complication
Confusional state
Ear pain

50-59:

Alanine aminotransferase increased
Blood bilirubin increased
Catheter site infection (infection at the site of insertion)
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Dyspnoea (difficult or laboured respiration)
Embolism venous (embolus may pass into the arterial system)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatine phosphokinase increased
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Acute respiratory distress syndrome
Dizziness
Abdominal pain
Blood alkaline phosphatase increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Infection: 8 people, 13.33%
Depression: 8 people, 13.33%
Oesophageal Candidiasis (fungal infection of oesophagus): 7 people, 11.67%
Arthritis Infective (purulent invasion of a joint by an infectious agent which produces arthritis): 7 people, 11.67%
Non-Small Cell Lung Cancer Stage Iiia: 4 people, 6.67%
Symphysiolysis (pain around the symphysis pubis join): 3 people, 5.00%
Stress And Anxiety: 3 people, 5.00%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 5.00%
Pilonidal Cyst: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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