Cogentin and Levothyroxine sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cogentin (benztropine mesylate) and Levothyroxine sodium (levothyroxine sodium). Common drug interactions include psychotic disorder among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Cogentin and Levothyroxine sodium. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

On Jul, 05, 2026

96 people who take Cogentin and Levothyroxine sodium together, and have interactions are studied.

Cogentin and Levothyroxine sodium drug interactions.

What are the common drug interactions of Cogentin and Levothyroxine Sodium, by gender? *:

female:

Psychotic disorder
Agitation (state of anxiety or nervous excitement)
Blood triglycerides increased
Diarrhoea
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Neutropenia (an abnormally low number of neutrophils)
Urinary tract infection
Abnormal behaviour
Aggression

male:

Aggression
Abdominal pain
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Leukocytosis (increased white blood cells)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Renal failure (kidney dysfunction)
Vision blurred
Blood glucose increased

What are the common drug interactions of Cogentin and Levothyroxine Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Disease complication
Megacolon (a very dilated colon)

20-29:

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Abdominal pain
Bradycardia (abnormally slow heart action)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dyspepsia (indigestion)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Leukocytosis (increased white blood cells)

30-39:

Ill-defined disorder
Type 2 diabetes mellitus
Somnolence (a state of near-sleep, a strong desire for sleep)
Depression
Suicide attempt
Blood pressure increased
Death
Fatigue (feeling of tiredness)
Heart rate increased

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Psychotic disorder
Type 2 diabetes mellitus
Aggression
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Confusion
Dizziness (excl vertigo)
Dyspnoea exertional (breathlessness or shortness of breath)

50-59:

Confusional state
Depressed level of consciousness
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug administration error
Dysphagia (a condition in which swallowing is difficult or painful)
Dystonia (abnormal muscle tone)
Erythema (redness of the skin)
Haematocrit decreased
Haemoglobin decreased

60+:

Leukopenia (less number of white blood cells in blood)
Psychotic disorder
Erythema (redness of the skin)
Fall
Hypertension (high blood pressure)
Lymphocyte count increased
Platelet count decreased
Small intestinal obstruction (blockage in small intestine)
Stress
Abdominal pain

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 15 people, 15.62%
Pain: 12 people, 12.50%
Psychotic Disorder: 9 people, 9.38%
Depression: 9 people, 9.38%
Stress And Anxiety: 8 people, 8.33%
Bipolar Disorder (mood disorder): 8 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.29%
Parkinson's Disease: 6 people, 6.25%
Insomnia (sleeplessness): 6 people, 6.25%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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