Colchicine and Creon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colchicine (colchicine) and Creon (pancrelipase (amylase;lipase;protease)). Common drug interactions include autoimmune disorder among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Colchicine and Creon. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Colchicine?

Colchicine has active ingredients of colchicine. It is often used in gout. eHealthMe is studying from 21,826 Colchicine users. Check the latest studies of Colchicine.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

82 people who take Colchicine and Creon together, and have interactions are studied.

What are the common drug interactions of Colchicine and Creon, by gender? *:

female:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Dyspnoea (difficult or laboured respiration)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Leukocytosis (increased white blood cells)
Migraine (headache)
Night sweats (sweating in night)
Oropharyngeal pain
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Diarrhoea
Cardiac flutter (abnormal heart rhythm)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Arthralgia (joint pain)
Bile duct stenosis (abnormal narrowing of the common bile duct)
Heart transplant
Long qt syndrome (disorder of the heart's electrical system)
Colitis (inflammation of colon)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Colchicine and Creon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Colitis (inflammation of colon)
Viral infection
Arthralgia (joint pain)
Dysuria (painful or difficult urination)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)

40-49:

Anal haemorrhage
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Lung transplant rejection (failure of lung transplant)

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood pressure decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Intestinal polyp (small growths in the bowel with the potential for further growth)
Pulmonary mass
Renal disorder (kidney disease)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

60+:

Chronic kidney disease
Hypokalaemia (low potassium)
Electrocardiogram qt prolonged
Constipation
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain
Bile duct stenosis (abnormal narrowing of the common bile duct)
Abdominal pain lower

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 17.07%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 12.20%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 10.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.76%
Vitamin B12 Deficiency: 7 people, 8.54%
Iron Deficiency: 7 people, 8.54%
Indigestion: 7 people, 8.54%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 6 people, 7.32%
Pain: 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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