Colchicine and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colchicine (colchicine) and Diflucan (fluconazole). Common drug interactions include fatigue among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Colchicine and Diflucan. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Colchicine?

Colchicine has active ingredients of colchicine. It is often used in gout. eHealthMe is studying from 21,826 Colchicine users. Check the latest studies of Colchicine.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

64 people who take Colchicine and Diflucan together, and have interactions are studied.

Colchicine and Diflucan drug interactions.

What are the common drug interactions of Colchicine and Diflucan, by gender? *:

female:

Fatigue (feeling of tiredness)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Pain
Arthralgia (joint pain)
Blood potassium increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough

male:

Diarrhoea
Petechiae (a small red or purple spot caused by bleeding into the skin)
Nausea (feeling of having an urge to vomit)
Febrile neutropenia (fever with reduced white blood cells)
Abdominal distension
Abdominal pain
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood pressure increased
Blood testosterone decreased

What are the common drug interactions of Colchicine and Diflucan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Cellulitis (infection under the skin)
Drug ineffective
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Blood testosterone decreased
Cardiac failure congestive
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Prostatic specific antigen increased
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Acute febrile neutrophilic dermatosis (skin disease characterized by the sudden onset of fever, leukocytosis, and tender)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Abdominal distension
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Headache (pain in head)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 29.69%
Pain: 17 people, 26.56%
High Blood Pressure: 10 people, 15.62%
Nausea (feeling of having an urge to vomit): 8 people, 12.50%
Hypersensitivity: 7 people, 10.94%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 9.38%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 7.81%
Constipation: 5 people, 7.81%
Depression: 5 people, 7.81%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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