Colchicine and Metaxalone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colchicine (colchicine) and Metaxalone (metaxalone). Common drug interactions include chronic kidney disease among females and systemic lupus erythematosus among males.

The phase IV clinical study analyzes what interactions people have when they take Colchicine and Metaxalone. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Colchicine?

Colchicine has active ingredients of colchicine. It is often used in gout. eHealthMe is studying from 21,826 Colchicine users. Check the latest studies of Colchicine.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

22 people who take Colchicine and Metaxalone together, and have interactions are studied.

Colchicine and Metaxalone drug interactions.

What are the common drug interactions of Colchicine and Metaxalone, by gender? *:

female:

Chronic kidney disease
Renal impairment (severely reduced kidney function)
Renal failure (kidney dysfunction)
Constipation
Nephropathy (damage to or disease of a kidney)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Accident
Disability
Drug ineffective
Hypertension (high blood pressure)

male:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Visual impairment
Pneumonia
Pulmonary mass
Renal cyst (kidney cyst)
Renal disorder (kidney disease)
Tobacco abuse
Chronic kidney disease
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Colchicine and Metaxalone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Infection
Influenza
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

n/a

50-59:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood pressure decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Intestinal polyp (small growths in the bowel with the potential for further growth)
Pulmonary mass
Renal cyst (kidney cyst)
Renal disorder (kidney disease)

60+:

Chronic kidney disease
Renal impairment (severely reduced kidney function)
Kawasaki's disease (an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed)
Kidney infection
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Obesity (having too much body fat)
Pneumonia
Pyelonephritis (inflammation of kidney caused by bacteria)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 40.91%
Pain: 8 people, 36.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 36.36%
Hypersensitivity: 6 people, 27.27%
Gastric Ph Decreased: 4 people, 18.18%
Joint Pain: 4 people, 18.18%
Drowsiness: 3 people, 13.64%
Insomnia (sleeplessness): 2 people, 9.09%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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