Combigan and Avapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combigan (brimonidine tartrate; timolol maleate) and Avapro (irbesartan). Common drug interactions include dizziness among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Combigan and Avapro. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Avapro?

Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.

On Jul, 14, 2026

20 people who take Combigan and Avapro together, and have interactions are studied.

What are the common drug interactions of Combigan and Avapro, by gender? *:

female:

Dizziness
Insomnia (sleeplessness)
Urinary tract infection
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood thyroid stimulating hormone increased
Constipation
Decreased appetite
Dysgeusia (disorder of the sense of taste)

male:

Arthralgia (joint pain)
Blood potassium increased
Spinal fracture (fracture in one of vertebrae)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperkalaemia (damage to or disease of the kidney)
Malignant melanoma (skin cancer rises from melancytes)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Combigan and Avapro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Dizziness
Insomnia (sleeplessness)
Pyrexia (fever)
Skin mass
Urinary tract infection
Arthralgia (joint pain)
Back pain
Bladder cancer
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood potassium increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 25.00%
Pain: 2 people, 10.00%
Constipation: 2 people, 10.00%
Indigestion: 2 people, 10.00%
Renal Cell Carcinoma (a kidney cancer): 2 people, 10.00%
Type 2 Diabetes: 1 person, 5.00%
Erection Problems: 1 person, 5.00%
Back Pain: 1 person, 5.00%
Blood Pressure Abnormal: 1 person, 5.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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