Combigan and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combigan (brimonidine tartrate; timolol maleate) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include dry mouth among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Combigan and Hyzaar. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 07, 2026

17 people who take Combigan and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Combigan and Hyzaar, by gender? *:

female:

Dry mouth
Heart rate irregular
Lethargy (tiredness)
Onychoclasis (breaking of the nails)
Skin hyperpigmentation (disorders affect the colour of your skin)
Breast pain
Chest discomfort
Eye pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Vision blurred

male:

Drug hypersensitivity
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Adverse event
Death
Fatigue (feeling of tiredness)
Throat irritation

What are the common drug interactions of Combigan and Hyzaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Drug hypersensitivity
Headache (pain in head)
Eye pain
Eye swelling
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Heart rate irregular
Lacrimation increased
Lethargy (tiredness)
Onychoclasis (breaking of the nails)

What are the existing conditions these people have? *

High Blood Cholesterol: 10 people, 58.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 29.41%
Diabetes: 4 people, 23.53%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 17.65%
Intraocular Pressure Increased: 2 people, 11.76%
Type 2 Diabetes: 1 person, 5.88%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.88%
Ocular Discomfort (a generic expression when there is lack of ease in/about the eyes): 1 person, 5.88%
Gout (uric acid crystals building up in the body): 1 person, 5.88%
Dry Eyes (lack of adequate tears): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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