Combipatch and Cardizem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combipatch (estradiol; norethindrone acetate) and Cardizem (diltiazem hydrochloride). Common drug interactions include depression among females.

The phase IV clinical study analyzes what interactions people have when they take Combipatch and Cardizem. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Cardizem?

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 28,014 Cardizem users. Check the latest studies of Cardizem.

On Jul, 05, 2026

21 people who take Combipatch and Cardizem together, and have interactions are studied.

Combipatch and Cardizem drug interactions.

What are the common drug interactions of Combipatch and Cardizem, by gender? *:

female:

Depression
Pain
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Back pain
Anxiety
Arthralgia (joint pain)
Balance disorder
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

male:

n/a

What are the common drug interactions of Combipatch and Cardizem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Overdose

50-59:

Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Peptic ulcer
Post polio syndrome
Proctalgia (pain in the rectum)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Repetitive strain injury
Sicca syndrome (the dryness of the eyes, mouth and other body parts is known as sicca syndrome)
Synovial cyst (cyst of joint filled with synovial fluid)

60+:

Depression
Pain
B-cell lymphoma (blood cancer affecting b cells)
Back pain
Breast cancer female
Cerebral atrophy (decrement in size of brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Decreased appetite
Dizziness
Intervertebral disc protrusion (spinal disc protrusion)

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 66.67%
Pain: 14 people, 66.67%
Meniere's Disease (a disorder of the inner ear that can affect hearing and balance to a varying degree): 14 people, 66.67%
High Blood Cholesterol: 14 people, 66.67%
Herpes Virus Infection: 14 people, 66.67%
Cardiac Disorder: 14 people, 66.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 10 people, 47.62%
Depression: 10 people, 47.62%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 14.29%
Oesophageal Spasm (contraction of oesophagus): 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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