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Compazine and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Compazine (prochlorperazine maleate) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include agitation among females and acute febrile neutrophilic dermatosis among males.

The phase IV clinical study analyzes what interactions people have when they take Compazine and Excedrin. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 17, 2026

66 people who take Compazine and Excedrin together, and have interactions are studied.

Compazine and Excedrin drug interactions.

What are the common drug interactions of Compazine and Excedrin, by gender? *:

female:

  1. Agitation (state of anxiety or nervous excitement)
  2. Anxiety disorder
  3. Arthropathy
  4. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  5. Back pain
  6. Blood pressure increased
  7. Cerebral venous thrombosis (clot in brains venous blood system)
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Ciliary body disorder
  10. Confusional state

male:

  1. Acute febrile neutrophilic dermatosis (skin disease characterized by the sudden onset of fever, leukocytosis, and tender)
  2. Dyspnoea (difficult or laboured respiration)
  3. Agitation (state of anxiety or nervous excitement)
  4. Anaemia (lack of blood)
  5. Anxiety
  6. Blood creatine decreased
  7. Blood creatine phosphokinase increased
  8. Bone pain
  9. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  10. Constipation

What are the common drug interactions of Compazine and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Asthma
  2. Cerebral venous thrombosis (clot in brains venous blood system)
  3. Pleuritic pain
  4. Sinusitis (inflammation of sinus)
  5. Transverse sinus thrombosis (a blood clot in transverse sinus)
  6. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  7. Chronic kidney disease
  8. Emotional distress
  9. Injury

30-39:

  1. Anogenital warts
  2. Blood hiv rna increased
  3. Kidney infection
  4. Renal failure (kidney dysfunction)
  5. Viral load increased
  6. Anaemia (lack of blood)
  7. Anxiety
  8. Depression
  9. Fatigue (feeling of tiredness)
  10. Fracture

40-49:

  1. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  2. Cough
  3. Emotional distress
  4. Injury
  5. Abdominal discomfort
  6. Abdominal pain
  7. Activities of daily living impaired
  8. Agitation (state of anxiety or nervous excitement)
  9. Anxiety disorder
  10. Arthralgia (joint pain)

50-59:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Constipation
  3. Death
  4. Decreased appetite
  5. Dehydration (dryness resulting from the removal of water)
  6. Diplopia (double vision)
  7. Dyspnoea (difficult or laboured respiration)
  8. Fatigue (feeling of tiredness)
  9. Flatulence (flatus expelled through the anus)
  10. Foot fracture

60+:

  1. Fatigue (feeling of tiredness)
  2. Abdominal distension
  3. Myalgia (muscle pain)
  4. Abdominal discomfort
  5. Drug ineffective
  6. Weight decreased
  7. Aphasia (damage to the parts of the brain that control language)
  8. Arthralgia (joint pain)
  9. Constipation
  10. Drooling (drop saliva uncontrollably from the mouth)

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 27 people, 40.91%
  2. Migraine (headache): 20 people, 30.30%
  3. Pain: 17 people, 25.76%
  4. Stress And Anxiety: 11 people, 16.67%
  5. Ovarian Cancer (cancer of ovary): 6 people, 9.09%
  6. Constipation: 6 people, 9.09%
  7. Insomnia (sleeplessness): 6 people, 9.09%
  8. High Blood Pressure: 5 people, 7.58%
  9. Back Pain: 5 people, 7.58%
  10. Diarrhea: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

Do you take Compazine and Excedrin?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Compazine and Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Compazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Compazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Excedrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on prochlorperazine maleate and acetaminophen; aspirin; caffeine (the active ingredients of Compazine and Excedrin, respectively), and Compazine and Excedrin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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