Norvasc and Zelboraf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norvasc (amlodipine besylate) and Zelboraf (vemurafenib). Common drug interactions include fatigue among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Norvasc and Zelboraf. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Norvasc?

Norvasc has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 136,738 Norvasc users. Check the latest studies of Norvasc.

What is Zelboraf?

Zelboraf has active ingredients of vemurafenib. eHealthMe is studying from 8,392 Zelboraf users. Check the latest studies of Zelboraf.

On Jul, 17, 2026

20 people who take Norvasc and Zelboraf together, and have interactions are studied.

What are the common drug interactions of Norvasc and Zelboraf, by gender? *:

female:

Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood uric acid increased
Rash erythematous (redness of the skin)
Rash macular (small, flat red spots)
Arthralgia (joint pain)
Rash
Alopecia (absence of hair from areas of the body)

male:

Death
Dyspepsia (indigestion)
Discomfort
Metastasis (spreadable cancer to other organ from origin)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Oedema peripheral (superficial swelling)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Anxiety
Diarrhoea
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Norvasc and Zelboraf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hypertriglyceridaemia (excess of triglycerides in the blood)

50-59:

Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Death
Oedema peripheral (superficial swelling)

60+:

Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Decreased appetite
Eosinophil count increased
Hypoaesthesia (reduced sense of touch or sensation)
Joint stiffness
Myalgia (muscle pain)
Oedema (fluid collection in tissue)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 8 people, 40.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 6 people, 30.00%
Insomnia (sleeplessness): 3 people, 15.00%
Thyroid Cancer: 3 people, 15.00%
Pain: 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Depression: 2 people, 10.00%
Diabetes: 2 people, 10.00%
Essential Hypertension (primary hypertension): 2 people, 10.00%
Urinary Tract Infection: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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