Compazine and Perjeta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Compazine (prochlorperazine maleate) and Perjeta (pertuzumab). Common drug interactions include seizure among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Compazine and Perjeta. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

What is Perjeta?

Perjeta has active ingredients of pertuzumab. eHealthMe is studying from 13,388 Perjeta users. Check the latest studies of Perjeta.

On Jul, 17, 2026

51 people who take Compazine and Perjeta together, and have interactions are studied.

Compazine and Perjeta drug interactions.

What are the common drug interactions of Compazine and Perjeta, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Skin exfoliation (removal of the oldest dead skin cells)
Suicide attempt
Syncope (loss of consciousness with an inability to maintain postural tone)
Tinea pedis (a contagious skin infection caused by the ringworm fungus)
Vaginal haemorrhage (vaginal bleeding)
White blood cell count increased
Blood urea increased
Cardiac disorder
Dry eye (lack of adequate tears)

male:

Chest pain
Haemoglobin decreased
Nocardia test positive
Osteolysis (dissolution of bone)
Pathological fracture (broken bone caused by disease)
Pleural effusion (water on the lungs)
Spinal compression fracture (fracture due to spinal compression on bone)
Staphylococcus test positive
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)

What are the common drug interactions of Compazine and Perjeta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Haemoglobin decreased
Wound haemorrhage (bleeding wound)
Acetabulum fracture (socket of the hip joint- fracture)
Constipation
Disease progression
Dyspnoea exertional (breathlessness or shortness of breath)
Enterococcus test positive
Fractured sacrum
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Neutropenia (an abnormally low number of neutrophils)
Nocturia (the need to get up in the night to urinate)
Otitis media (inflammation of the middle ear)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pathological fracture (broken bone caused by disease)
Peripheral swelling
Pneumonia viral
Pruritus (severe itching of the skin)
Dry eye (lack of adequate tears)
Dysphonia (speech disorder attributable to a disorder of phonation)

50-59:

Hair colour changes
Alopecia (absence of hair from areas of the body)
Diarrhoea
Hair disorder
Anxiety
Asthenia (weakness)
Depression
Fatigue (feeling of tiredness)
Neuropathy peripheral (surface nerve damage)
Rash erythematous (redness of the skin)

60+:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Red cell distribution width increased
White blood cell count decreased
Hair disorder
Blood urea increased
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Lymphocyte count increased
Monocyte count increased

What are the existing conditions these people have? *

Breast Cancer Female: 18 people, 35.29%
Nausea (feeling of having an urge to vomit): 14 people, 27.45%
Breast Cancer: 13 people, 25.49%
Stress And Anxiety: 7 people, 13.73%
Pain: 7 people, 13.73%
Breast Cancer Metastatic: 7 people, 13.73%
Diarrhea: 5 people, 9.80%
Breast Cancer Stage Ii: 4 people, 7.84%
Constipation: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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