Comtan and Eldepryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Eldepryl (selegiline hydrochloride). Common drug interactions include obsessive-compulsive disorder among females and pathological gambling among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Eldepryl. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Eldepryl?

Eldepryl has active ingredients of selegiline hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 752 Eldepryl users. Check the latest studies of Eldepryl.

On Jul, 16, 2026

64 people who take Comtan and Eldepryl together, and have interactions are studied.

What are the common drug interactions of Comtan and Eldepryl, by gender? *:

female:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Stress
Suicidal ideation
Affective disorder (mental disorder)
Eye irritation
Impulse-control disorder
Blood creatine phosphokinase increased

male:

Pathological gambling
Depression
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Suicide attempt
Abdominal pain
Abdominal pain upper
Adjustment disorder with depressed mood
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Back pain

What are the common drug interactions of Comtan and Eldepryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Rash papular (redness with papule)
Rectal haemorrhage (bleeding from anus)
Stress
Suicidal ideation
Upper respiratory tract infection
Anxiety
Depression
Pathological gambling
Benign prostatic hyperplasia (benign enlargement of the prostate)
Change of bowel habit

50-59:

Affective disorder (mental disorder)
Anxiety
Emotional distress
Fear
Impulse-control disorder
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pain
Pathological gambling
Alanine aminotransferase increased
Arthralgia (joint pain)

60+:

Depression
Emotional distress
Hyperglycaemia (high blood sugar)
Hyperpyrexia (extremely high fever)
Hypotension (abnormally low blood pressure)
Pallor
Pathological gambling
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Depression: 17 people, 26.56%
High Blood Pressure: 12 people, 18.75%
Pain: 9 people, 14.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 14.06%
Stress And Anxiety: 7 people, 10.94%
Glaucoma (increased fluid pressure in the eye with vision loss): 6 people, 9.38%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 9.38%
Back Pain: 6 people, 9.38%
Cataract (clouding of the lens inside the eye): 6 people, 9.38%
Dyslipidaemia (abnormal amount of lipids): 6 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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