Concerta and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Concerta (methylphenidate hydrochloride) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include somnolence among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Concerta and Sudafed. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 25,040 Concerta users. Check the latest studies of Concerta.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 16, 2026

52 people who take Concerta and Sudafed together, and have interactions are studied.

What are the common drug interactions of Concerta and Sudafed, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Anxiety
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Sinusitis (inflammation of sinus)
Blood pressure increased
Dry mouth
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypertension (high blood pressure)
Irritability

male:

Hypertension (high blood pressure)
Fatigue (feeling of tiredness)
Peripheral swelling
Pneumonia
Pruritus (severe itching of the skin)
Skin disorder (skin disease)
Tenderness (pain or discomfort when an affected area is touched)
Urine amphetamine positive
Arthralgia (joint pain)
Drug abuse

What are the common drug interactions of Concerta and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Eye swelling

10-19:

Drug abuse
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hepatitis (inflammation of the liver)
Migraine (headache)
Pneumonia
Pruritus (severe itching of the skin)
Urine amphetamine positive

20-29:

Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Polydipsia (excessive thirst)
Thirst
Abdominal pain upper
Anxiety
Balance disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)

30-39:

Fatigue (feeling of tiredness)
Gestational diabetes (diabetes in pregnancy)
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug exposure during pregnancy
Erythromelalgia (episodes of pain, redness, and swelling in various parts of the body)

40-49:

Hypertension (high blood pressure)
Erythema (redness of the skin)
Inflammation
Peripheral swelling
Tenderness (pain or discomfort when an affected area is touched)

50-59:

n/a

60+:

Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 32 people, 61.54%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 38.46%
Drowsiness: 5 people, 9.62%
Hypersensitivity: 4 people, 7.69%
Asthma: 4 people, 7.69%
Allergic Sinusitis: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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