Hydramine and Actiq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Actiq (fentanyl citrate). Common drug interactions include bone disorder among females and multiple drug overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Actiq. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

On Jul, 16, 2026

20 people who take Hydramine and Actiq together, and have interactions are studied.

What are the common drug interactions of Hydramine and Actiq, by gender? *:

female:

Bone disorder
Breast cancer metastatic
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Compression fracture (fracture due to pressure caused by injury)
Deafness
Dental caries
Depression
Disability
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Gastritis (inflammation of stomach)

male:

Multiple drug overdose
Suicidal ideation

What are the common drug interactions of Hydramine and Actiq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Drug abuse

40-49:

Anaemia of malignant disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Axillary mass
Bone disorder
Breast cancer metastatic
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Compression fracture (fracture due to pressure caused by injury)
Deafness
Dental caries

50-59:

Death
Drug abuse

60+:

Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Ejection fraction decreased (systolic heart failure)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 10 people, 50.00%
Multiple Myeloma (cancer of the plasma cells): 4 people, 20.00%
Stress And Anxiety: 1 person, 5.00%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 5.00%
Nausea (feeling of having an urge to vomit): 1 person, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.00%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 1 person, 5.00%
Immunodeficiency Common Variable: 1 person, 5.00%
Headache (pain in head): 1 person, 5.00%
Cough: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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