Contrave and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include stress among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Flexeril. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 29, 2026

18 people who take Contrave and Flexeril together, and have interactions are studied.

Contrave and Flexeril drug interactions.

What are the common drug interactions of Contrave and Flexeril, by gender? *:

female:

Stress
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Neck pain
Nephritis (inflammation of the nephrons in the kidneys)
Therapeutic response unexpected
Weight increased

male:

Abdominal pain upper
Fatigue (feeling of tiredness)
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Memory impairment
Thyroid cancer

What are the common drug interactions of Contrave and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Memory impairment
Nausea (feeling of having an urge to vomit)
Somnambulism (sleep walking)
Stomatitis (inflammation of mucous membrane of mouth)

40-49:

Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neck pain
Nephritis (inflammation of the nephrons in the kidneys)
Therapeutic response unexpected
Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Weight increased

50-59:

Fatigue (feeling of tiredness)
Memory impairment
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

60+:

Chronic kidney disease
Headache (pain in head)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Nephrogenic anaemia (anaemia due to kidney disease)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 50.00%
Depression: 7 people, 38.89%
Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 6 people, 33.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 33.33%
Oedema Peripheral (superficial swelling): 6 people, 33.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 33.33%
Weight Decreased: 4 people, 22.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 16.67%
Drowsiness: 2 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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