Contrave and Lopurin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Lopurin (allopurinol). Common drug interactions include atrial fibrillation among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Lopurin. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Lopurin?

Lopurin has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,798 Lopurin users. Check the latest studies of Lopurin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

42 people who take Contrave and Lopurin together, and have interactions are studied.

What are the common drug interactions of Contrave and Lopurin, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disease recurrence
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Nasopharyngitis (inflammation of the nasopharynx)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Thirst
Urinary tract infection

male:

Dizziness
Blood pressure increased
Agitation (state of anxiety or nervous excitement)
Chills (felling of cold)
Confusional state
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Feeling of body temperature change
Haematuria (presence of blood in urine)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Contrave and Lopurin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Blood pressure increased
Dizziness
Dry mouth
Erectile dysfunction
Hangover
Blood pressure decreased
Memory impairment
Panic attack

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dizziness
Heart rate increased
Dyspnoea (difficult or laboured respiration)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Suicidal ideation
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 45.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 33.33%
Depression: 11 people, 26.19%
High Blood Cholesterol: 10 people, 23.81%
Immunodeficiency Common Variable: 9 people, 21.43%
Blood Pressure Abnormal: 9 people, 21.43%
Primary Immunodeficiency Syndrome: 6 people, 14.29%
Blood Uric Acid Increased: 6 people, 14.29%
Weight Decreased: 4 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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