Contrave and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Zoloft (sertraline hydrochloride). Common drug interactions include constipation among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Zoloft. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 06, 2026

45 people who take Contrave and Zoloft together, and have interactions are studied.

What are the common drug interactions of Contrave and Zoloft, by gender? *:

female:

Constipation
Diarrhoea
Vision blurred
Drug ineffective
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Suicidal ideation
Back pain
Dizziness
Migraine (headache)
Pain

male:

Dizziness
Dry mouth
Vertigo

What are the common drug interactions of Contrave and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mood swings (an extreme or rapid change in mood)
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Agitation (state of anxiety or nervous excitement)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Diarrhoea
Dizziness
Dry mouth

40-49:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain
Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Apathy
Body temperature increased
Diarrhoea
Heart rate increased

50-59:

Dehydration (dryness resulting from the removal of water)
Dry mouth
Food craving
Headache (pain in head)
Muscle spasms (muscle contraction)
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Insomnia (sleeplessness)

60+:

Drug ineffective
Blood pressure increased
Dizziness
Feeling jittery
Hyperacusis (disorder in loudness perception)
Irritability
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 17.78%
Stress And Anxiety: 7 people, 15.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.11%
Weight Decreased: 4 people, 8.89%
High Blood Cholesterol: 4 people, 8.89%
Pain: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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