Cordarone and Mysoline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cordarone (amiodarone hydrochloride) and Mysoline (primidone). Common drug interactions include hospitalisation among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Cordarone and Mysoline. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Cordarone?

Cordarone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 22,776 Cordarone users. Check the latest studies of Cordarone.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

25 people who take Cordarone and Mysoline together, and have interactions are studied.

Cordarone and Mysoline drug interactions.

What are the common drug interactions of Cordarone and Mysoline, by gender? *:

female:

Hospitalisation
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Anaemia (lack of blood)
Neuropathy peripheral (surface nerve damage)
Aortic valve calcification
Aortic valve disease
Arterial disorder
Arteriosclerosis (thickening and hardening of arteries)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)

male:

Agitation (state of anxiety or nervous excitement)
Persecutory delusion
Acute respiratory distress syndrome
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Balance disorder
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Kyphoscoliosis (abnormal curving of the spine)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Renal failure (kidney dysfunction)

What are the common drug interactions of Cordarone and Mysoline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Blindness
Cardiac failure
Cardiac murmur (an heart sound in valve abnormality)
Cardiac valve disease (heart valve disease)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Chest pain
Cough

What are the existing conditions these people have? *

Essential Tremor: 4 people, 16.00%
Oedema (fluid collection in tissue): 3 people, 12.00%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 8.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 8.00%
Constipation: 2 people, 8.00%
Cardiac Failure: 2 people, 8.00%
Arrhythmias (irregular heartbeat): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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