Lorcet-hd and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate), especially for people who are female, 60+ old, also take Protonix, and have Metastases to bone.

The phase IV clinical study analyzes which people have Osteoporosis when taking Lorcet-hd. It is created by eHealthMe based on reports of 2,140 people who have side effects when taking Lorcet-hd from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,806 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Osteoporosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

2,140 people reported to have side effects when taking Lorcet-hd.
Among them, 36 people (1.68%) have Osteoporosis.

Among these 36 people:

What is the gender of people who have Osteoporosis when taking Lorcet-hd? *

female: 97.22 %
male: 2.78 %

What is the age of people who have Osteoporosis when taking Lorcet-hd? *

What are other drugs people take besides Lorcet-hd? *

What are other side effects people have besides Osteoporosis? *

Anaemia (lack of blood): 30 people, 83.33%
Weight Decreased: 28 people, 77.78%
Chest Pain: 28 people, 77.78%
Computerised Tomogram Abnormal: 27 people, 75.00%
Lung Neoplasm (tumour of lung): 26 people, 72.22%
Fatigue (feeling of tiredness): 26 people, 72.22%
Bone Scan Abnormal: 26 people, 72.22%
Fall: 26 people, 72.22%
Constipation: 26 people, 72.22%
Impaired Healing: 26 people, 72.22%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 26 people, 72.22%
Nausea (feeling of having an urge to vomit): 4 people, 11.11%
Chest Pain: 4 people, 11.11%
High Blood Pressure: 3 people, 8.33%
Muscle Spasms (muscle contraction): 2 people, 5.56%
Arrhythmias (irregular heartbeat): 2 people, 5.56%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 2.78%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 2.78%
High Blood Cholesterol: 1 person, 2.78%
Dyspnea (difficult or laboured breathing): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Lorcet-hd and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lorcet-hd:

Lorcet-hd (2,221 reports)

Osteoporosis treatments and more:

Osteoporosis (290,735 reports)

How severe was Osteoporosis and when was it recovered:

Osteoporosis in Lorcet-hd

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Osteoporosis and drugs with ingredients of acetaminophen; hydrocodone bitartrate (1,912 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lorcet-hd:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Osteoporosis (1,806 drugs)

Browse all the conditions that are associated with Osteoporosis:

Osteoporosis (1,905 conditions)

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lorcet-hd) and Lorcet-hd (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.