Coreg and Climara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coreg (carvedilol) and Climara (estradiol). Common drug interactions include chest pain among females.

The phase IV clinical study analyzes what interactions people have when they take Coreg and Climara. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

On Aug, 03, 2026

16 people who take Coreg and Climara together, and have interactions are studied.

What are the common drug interactions of Coreg and Climara, by gender? *:

female:

Chest pain
Dyspnoea (difficult or laboured respiration)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Intestinal obstruction
Ovarian adhesion (bands of scar-like tissue that form between ovary and nearby organ)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pelvic adhesions
Pelvic pain
Salpingitis (an infection and inflammation in the fallopian tubes)

male:

n/a

What are the common drug interactions of Coreg and Climara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chest pain
Dyspepsia (indigestion)
Anxiety
Arteriovenous fistula site infection
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Mastoiditis (infection of mastoid bone)

50-59:

Costochondritis (chest wall pain)
Depression
Dyspareunia (painful sexual intercourse)
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Intestinal obstruction
Ovarian adhesion (bands of scar-like tissue that form between ovary and nearby organ)

60+:

Catheter site infection (infection at the site of insertion)
Immunosuppression
Klebsiella infection
Cystitis (inflammation of the wall of the bladder)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 37.50%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 5 people, 31.25%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 18.75%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 18.75%
Chronic Kidney Disease: 2 people, 12.50%
Constipation: 2 people, 12.50%
Stress And Anxiety: 2 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 12.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 12.50%
Nausea And Vomiting: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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