Coreg and Corgard drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Coreg (carvedilol) and Corgard (nadolol). Common drug interactions include decreased appetite among females and atrial fibrillation among males.
The phase IV clinical study analyzes what interactions people have when they take Coreg and Corgard. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.
What is Coreg?
Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.
What is Corgard?
Corgard has active ingredients of nadolol. It is often used in high blood pressure. eHealthMe is studying from 3,342 Corgard users. Check the latest studies of Corgard.
19 people who take Coreg and Corgard together, and have interactions are studied.

What are the common drug interactions of Coreg and Corgard, by gender? *:
female:
- Decreased appetite
- Epistaxis (bleed from the nose)
- Fatigue (feeling of tiredness)
- Low density lipoprotein increased (cholesterol increased in blood)
- Myalgia (muscle pain)
- Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
- Urinary tract infection
- Abasia (inability to walk)
- Abdominal discomfort
- Activities of daily living impaired
male:
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Pain
- Rectal haemorrhage (bleeding from anus)
- Abdominal pain
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Cardiac failure congestive
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Cardiogenic shock (inadequate circulation of blood)
- Cardiomegaly (increased size of heart than normal)
What are the common drug interactions of Coreg and Corgard, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Acute myocardial infarction (acute heart attack)
- Anxiety
- Balance disorder
- Blindness
- Cardiac failure
- Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
- Depression
- Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
- Hypersensitivity
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
50-59:
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Cardiac perforation (a hole in heart)
- Cardiac tamponade (fluid accumulates in heart covering)
- Chills (felling of cold)
- Coronary artery thrombosis (clot formation in coronary artery)
- Cough
- Dizziness
- Effusion (an escape of fluid into a body cavity)
- Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
- Hypoaesthesia (reduced sense of touch or sensation)
60+:
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Cardiac failure congestive
- Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
- Diabetes mellitus inadequate control
- Emotional distress
- Hypokalaemia (low potassium)
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
- Occult blood positive
- Orthopnoea (shortness of breath (dyspnea) when lying down)
- Palpitations (feelings or sensations that your heart is pounding or racing)
What are the existing conditions these people have? *
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 52.63%
- Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 15.79%
- Pulmonary Oedema (fluid accumulation in the lungs): 2 people, 10.53%
- Pain: 2 people, 10.53%
- Cerebral Disorder (brain disease): 2 people, 10.53%
- Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
- Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 1 person, 5.26%
- Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 5.26%
- Asthma: 1 person, 5.26%
- Bipolar Disorder (mood disorder): 1 person, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Coreg and Corgard?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Coreg and Corgard:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Coreg:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Corgard:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Coreg and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Corgard and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carvedilol and nadolol (the active ingredients of Coreg and Corgard, respectively), and Coreg and Corgard (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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