Coreg and Divalproex sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coreg (carvedilol) and Divalproex sodium (divalproex sodium). Common drug interactions include injection site haematoma among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Coreg and Divalproex sodium. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

On Jul, 15, 2026

23 people who take Coreg and Divalproex sodium together, and have interactions are studied.

Coreg and Divalproex sodium drug interactions.

What are the common drug interactions of Coreg and Divalproex Sodium, by gender? *:

female:

Injection site haematoma (localized swelling filled with blood at injection site)
Injection site swelling
Irritability
Ketonuria (ketones in urine)
Leukopenia (less number of white blood cells in blood)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Nervousness
Obesity (having too much body fat)
Occult blood positive

male:

Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Haemorrhage (bleeding)
Hallucination, visual (seeing things that aren't there)
Intestinal perforation (complete penetration of the wall of the intestine)
Lipase increased
Lymphocyte count decreased
Malaise (a feeling of general discomfort or uneasiness)
Mania (a state of abnormally elevated or irritable mood)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)

What are the common drug interactions of Coreg and Divalproex Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gastrointestinal inflammation (inflammation of stomach and intestine)
Headache (pain in head)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site swelling
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Weight increased
Vomiting

40-49:

Arrhythmia (irregular heartbeat)
Blood alkaline phosphatase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diabetes mellitus non-insulin-dependent
Glycosuria (excretion of glucose into the urine)
High density lipoprotein decreased
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperglycaemia (high blood sugar)
Hypertriglyceridaemia (excess of triglycerides in the blood)

50-59:

Death
Agitation (state of anxiety or nervous excitement)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Drug ineffective
Dry mouth
Gastric disorder (disease of stomach)
Granulocytopenia (lack of granulocyte)
Irritability
Leukopenia (less number of white blood cells in blood)

60+:

Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Haemorrhage (bleeding)
Hallucination, visual (seeing things that aren't there)
Intestinal perforation (complete penetration of the wall of the intestine)
Lipase increased
Lymphocyte count decreased
Malaise (a feeling of general discomfort or uneasiness)
Mania (a state of abnormally elevated or irritable mood)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 13.04%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 13.04%
Bipolar Disorder (mood disorder): 3 people, 13.04%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 8.70%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 8.70%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 2 people, 8.70%
Insomnia (sleeplessness): 2 people, 8.70%
Hyperkalemia (damage to or disease of the kidney): 2 people, 8.70%
Gout (uric acid crystals building up in the body): 2 people, 8.70%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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