Coreg and Entecavir drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Coreg (carvedilol) and Entecavir (entecavir). Common drug interactions include chronic kidney disease among females and musculoskeletal pain among males.
The phase IV clinical study analyzes what interactions people have when they take Coreg and Entecavir. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.
What is Coreg?
Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.
What is Entecavir?
Entecavir has active ingredients of entecavir. It is often used in hepatitis b. eHealthMe is studying from 7,354 Entecavir users. Check the latest studies of Entecavir.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
15 people who take Coreg and Entecavir together, and have interactions are studied.

What are the common drug interactions of Coreg and Entecavir, by gender? *:
female:
- Chronic kidney disease
- Renal injury (kidney injury)
- Hypotension (abnormally low blood pressure)
- Respiratory distress (difficulty in breathing)
- Anaemia (lack of blood)
- Anxiety
- Blood creatinine increased
- Depression
- Dyspnoea (difficult or laboured respiration)
- Empyema (collection of pus in a cavity in the body)
male:
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Neuralgia (pain in one or more nerves)
- Rectal haemorrhage (bleeding from anus)
- Renal failure (kidney dysfunction)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Chronic kidney disease
- Death
- Emotional distress
- Nephrolithiasis (calculi in the kidneys)
What are the common drug interactions of Coreg and Entecavir, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Chronic kidney disease
- Renal injury (kidney injury)
- Anxiety
- Blood creatinine increased
- Depression
- Nephrogenic anaemia (anaemia due to kidney disease)
- Renal failure (kidney dysfunction)
- Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
- Renal hypertension (high blood pressure caused by the kidneys hormonal response)
40-49:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Chronic kidney disease
- Death
- Emotional distress
- Nephrolithiasis (calculi in the kidneys)
- Pain
- Proteinuria (presence of protein in the urine)
- Renal failure (kidney dysfunction)
50-59:
n/a
60+:
- Hypotension (abnormally low blood pressure)
- Respiratory distress (difficulty in breathing)
- Acute respiratory failure
- Hypoxia (low oxygen in tissues)
- Leukocytosis (increased white blood cells)
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
- Pleural effusion (water on the lungs)
- Rectal haemorrhage (bleeding from anus)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Urine output decreased
What are the existing conditions these people have? *
- Pain: 5 people, 33.33%
- Nausea And Vomiting: 3 people, 20.00%
- Nausea (feeling of having an urge to vomit): 3 people, 20.00%
- Hiv Infection: 3 people, 20.00%
- Fever: 3 people, 20.00%
- Renal Disorder (kidney disease): 2 people, 13.33%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
- Bipolar Disorder (mood disorder): 2 people, 13.33%
- Cough: 2 people, 13.33%
- Diabetes: 2 people, 13.33%
* Approximation only. Some reports may have incomplete information.
Do you take Coreg and Entecavir?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Coreg and Entecavir:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Coreg:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Entecavir:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Coreg and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Entecavir and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carvedilol and entecavir (the active ingredients of Coreg and Entecavir, respectively), and Coreg and Entecavir (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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