Coreg and Lupron depot drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Coreg (carvedilol) and Lupron depot (leuprolide acetate). Common drug interactions include erythema among females and fatigue among males.
The phase IV clinical study analyzes what interactions people have when they take Coreg and Lupron depot. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.
What is Coreg?
Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.
What is Lupron depot?
Lupron depot has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 27,037 Lupron depot users. Check the latest studies of Lupron depot.
55 people who take Coreg and Lupron depot together, and have interactions are studied.

What are the common drug interactions of Coreg and Lupron Depot, by gender? *:
female:
- Erythema (redness of the skin)
- Flushing (the warm, red condition of human skin)
- Influenza like illness
- Loss of consciousness
- Pruritus generalised (generalized itching)
- Vision blurred
- Blood creatine phosphokinase increased
- Migraine (headache)
- Therapeutic response unexpected
- Abdominal pain lower
male:
- Fatigue (feeling of tiredness)
- Hypotension (abnormally low blood pressure)
- Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
- Anaemia (lack of blood)
- Blood iron increased
- Cardiac disorder
- Confusional state
- Hallucination (an experience involving the perception of something not present)
- Malignant neoplasm progression (cancer tumour came back)
- Metastases to bone (cancer spreads to bone)
What are the common drug interactions of Coreg and Lupron Depot, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Blood creatine phosphokinase increased
- Menstruation irregular
40-49:
- Vaginal haemorrhage (vaginal bleeding)
- Migraine (headache)
- Mood swings (an extreme or rapid change in mood)
- Therapeutic response unexpected
- Abdominal pain lower
- Anxiety
- Disturbance in attention
- Dizziness
- Drug ineffective
- Dyspnoea (difficult or laboured respiration)
50-59:
- Abnormal dreams
- Alopecia (absence of hair from areas of the body)
- Anaemia (lack of blood)
- Blood iron increased
- Depressed mood
- Diarrhoea
- Dizziness
- Dry mouth
- Dyspnoea (difficult or laboured respiration)
- Erythema (redness of the skin)
60+:
- Hypotension (abnormally low blood pressure)
- Blood calcium decreased
- Metastases to bone (cancer spreads to bone)
- Renal disorder (kidney disease)
- Blood glucose increased
- Hyperhidrosis (abnormally increased sweating)
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Prostate cancer metastatic
- Prostatomegaly (enlargement of the prostate)
- Rib fracture
What are the existing conditions these people have? *
- Prostate Cancer: 25 people, 45.45%
- Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 7 people, 12.73%
- High Blood Cholesterol: 7 people, 12.73%
- Pain: 4 people, 7.27%
- Multiple Myeloma (cancer of the plasma cells): 4 people, 7.27%
- Cardiac Disorder: 4 people, 7.27%
- Stress And Anxiety: 3 people, 5.45%
- Diabetes: 3 people, 5.45%
- Cough: 3 people, 5.45%
* Approximation only. Some reports may have incomplete information.
Do you take Coreg and Lupron depot?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Coreg (49,583 reports)
- Lupron depot (27,037 reports)
Browse all drug interactions of Coreg and Lupron depot:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Coreg:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Lupron depot:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Coreg and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Lupron depot and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Sharma SP, Muggia F, "Supraventricular tachycardia and urticaria complicating leuprolide-induced ovarian suppression in a young woman with breast cancer: a case report", ecancermedicalscience, 2016 Jan .
- Pong YH, Lu YC, Tsai VF, Huang PL, Hsieh JT, Chang HC, "Acute manic and psychotic symptoms following subcutaneous leuprolide acetate in a male patient without prior psychiatric history: A case report and literature review", Urological Science, 2014 Mar .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Sharma SP, Muggia F, "Supraventricular tachycardia and urticaria complicating leuprolide-induced ovarian suppression in a young woman with breast cancer: a case report", ecancermedicalscience, 2016 Jan .
- Pong YH, Lu YC, Tsai VF, Huang PL, Hsieh JT, Chang HC, "Acute manic and psychotic symptoms following subcutaneous leuprolide acetate in a male patient without prior psychiatric history: A case report and literature review", Urological Science, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on carvedilol and leuprolide acetate (the active ingredients of Coreg and Lupron depot, respectively), and Coreg and Lupron depot (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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