Coreg and Sublimaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coreg (carvedilol) and Sublimaze (fentanyl citrate). Common drug interactions include corneal opacity among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Coreg and Sublimaze. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

On Jul, 13, 2026

29 people who take Coreg and Sublimaze together, and have interactions are studied.

What are the common drug interactions of Coreg and Sublimaze, by gender? *:

female:

Corneal opacity (scarring or clouding of the cornea)
Depression
Dizziness
Dyspnoea (difficult or laboured respiration)
Fear
Heart rate irregular
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)
Mitral valve calcification (calcium deposit in mitral valve)
Multiple injuries

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Abscess limb (limb infection)
Anaemia postoperative
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bacteraemia (presence of bacteria in the blood)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Coreg and Sublimaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Antibody test positive
Proteinuria (presence of protein in the urine)
Renal failure acute (rapid kidney dysfunction)

30-39:

Anaemia (lack of blood)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Vomiting
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)

40-49:

n/a

50-59:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Acute respiratory failure
Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Bone density decreased
Cardiac failure congestive
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Emotional distress
Fluid overload (too much fluid in the blood)

60+:

Renal failure (kidney dysfunction)
Loss of consciousness
Renal failure acute (rapid kidney dysfunction)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Abdominal discomfort
Anaemia postoperative
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

What are the existing conditions these people have? *

Pain: 7 people, 24.14%
Diabetes: 5 people, 17.24%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 13.79%
Nausea (feeling of having an urge to vomit): 4 people, 13.79%
Constipation: 4 people, 13.79%
Cardiac Disorder: 3 people, 10.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.34%
Weight Decreased: 2 people, 6.90%
Hyperglycemia (high blood sugar): 2 people, 6.90%
Blood Pressure Abnormal: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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