Corgard and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Corgard (nadolol) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include hepatic steatosis among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Corgard and Flexeril. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Corgard?

Corgard has active ingredients of nadolol. It is often used in high blood pressure. eHealthMe is studying from 3,342 Corgard users. Check the latest studies of Corgard.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

70 people who take Corgard and Flexeril together, and have interactions are studied.

What are the common drug interactions of Corgard and Flexeril, by gender? *:

female:

Hepatic steatosis (fatty liver disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Syncope (loss of consciousness with an inability to maintain postural tone)
Atelectasis (partial or complete collapse of the lung)
Coronary artery stenosis (narrowing of coronary artery)
Facial pain
Multiple injuries
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oxygen saturation decreased
Pain

male:

Anaemia (lack of blood)
Anxiety
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased interest
Dental caries

What are the common drug interactions of Corgard and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain lower
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Electrolyte imbalance
Fatigue (feeling of tiredness)
Influenza like illness
Injection site bruising
Injection site erythema (redness at injection site)
Injection site inflammation
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

30-39:

Application site reaction
Burns
Crying
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

40-49:

Body temperature increased
Completed suicide (act of taking one's own life)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Ear discomfort
Ear pain
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Optic neuritis (optic nerve inflammation)
Overdose
Pain

50-59:

Dyspepsia (indigestion)
Pain
Pain in extremity
Anaemia (lack of blood)
Chest pain
Hepatic steatosis (fatty liver disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Tremor (trembling or shaking movements in one or more parts of your body)
Atelectasis (partial or complete collapse of the lung)
Coronary artery stenosis (narrowing of coronary artery)

60+:

Pain
Anxiety
Calcinosis (calcium deposits in any soft tissue)
Cellulitis (infection under the skin)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Diarrhoea
Fall
Fatigue (feeling of tiredness)
Food poisoning (poison in food)
Gait disturbance

What are the existing conditions these people have? *

Pain: 12 people, 17.14%
Migraine (headache): 8 people, 11.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 8.57%
Stress And Anxiety: 5 people, 7.14%
Diabetes: 5 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 4 people, 5.71%
Birth Control: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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