Corlanor and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Corlanor (ivabradine hydrochloride) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include pain among females and central nervous system lesion among males.

The phase IV clinical study analyzes what interactions people have when they take Corlanor and Flexeril. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Corlanor?

Corlanor has active ingredients of ivabradine hydrochloride. eHealthMe is studying from 2,453 Corlanor users. Check the latest studies of Corlanor.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 17, 2026

18 people who take Corlanor and Flexeril together, and have interactions are studied.

Corlanor and Flexeril drug interactions.

What are the common drug interactions of Corlanor and Flexeril, by gender? *:

female:

Pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cough
Exostosis (formation of new bone on the surface of a bone)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypersensitivity
Injection site bruising
Injection site pain
Injection site rash
Pain in extremity

male:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebellar infarction (impaired blood circulation to cerebellum)
Nephrolithiasis (calculi in the kidneys)
Night sweats (sweating in night)
Protein s deficiency
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Thrombocytosis
Type 2 diabetes mellitus
Vision blurred

What are the common drug interactions of Corlanor and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Inflammatory marker increased
Injection site bruising
Injection site pain
Injection site ulcer
Upper respiratory tract infection

30-39:

n/a

40-49:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Dry skin
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Sleep disorder
Visual impairment

50-59:

Dyspnoea (difficult or laboured respiration)
Folate deficiency (lack of folic acid)
Headache (pain in head)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrolithiasis (calculi in the kidneys)
Night sweats (sweating in night)
Protein s deficiency
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)

60+:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Fall
Psychotic disorder
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the existing conditions these people have? *

Hypersensitivity: 3 people, 16.67%
Nausea (feeling of having an urge to vomit): 3 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 16.67%
Pain: 3 people, 16.67%
Asthma: 2 people, 11.11%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 11.11%
Stress And Anxiety: 2 people, 11.11%
Muscle Disorder (muscle disease): 2 people, 11.11%
Arrhythmias (irregular heartbeat): 2 people, 11.11%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Corlanor and Flexeril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously