Cortef and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Atarax (hydroxyzine hydrochloride). Common drug interactions include fatigue among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Atarax. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

On Jul, 30, 2026

18 people who take Cortef and Atarax together, and have interactions are studied.

What are the common drug interactions of Cortef and Atarax, by gender? *:

female:

Fatigue (feeling of tiredness)
Abscess (pus)
C-reactive protein increased
Drug ineffective
Drug effect delayed
Abdominal discomfort
Ageusia (loss of taste functions of the tongue)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

male:

Death
Lung disorder (lung disease)
Neutropenia (an abnormally low number of neutrophils)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Hospitalisation
Hypophysitis (inflammation of the pituitary gland)
Overdose
Pneumonia bacterial (pneumonia associated with bacterial infection)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Cortef and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

20-29:

n/a

30-39:

Drug effect delayed
Fatigue (feeling of tiredness)

40-49:

Alanine aminotransferase increased
Analgesic drug level increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood urea increased
Blood urea nitrogen/creatinine ratio increased
Decreased appetite
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

Abscess (pus)
C-reactive protein increased
Abdominal discomfort
Ageusia (loss of taste functions of the tongue)
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anosmia (partial or complete loss of the sense of smell)
Cancer in remission (a decrease in or disappearance of signs and symptoms of cancer)
Cervix carcinoma stage iv (cancer has spread to the bladder, rectum, or other parts of the body)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

60+:

Lung disorder (lung disease)
Neutropenia (an abnormally low number of neutrophils)
Meningioma benign (non cancer tumour of membranes that cover the brain and spinal cord just inside the skull)
Migraine (headache)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Anticoagulation drug level above therapeutic
Bone marrow disorder
Death
Drug ineffective
Gastritis (inflammation of stomach)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 22.22%
Constipation: 4 people, 22.22%
Itching: 4 people, 22.22%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 16.67%
Sleep Disorder: 3 people, 16.67%
Dyspnea (difficult or laboured breathing): 3 people, 16.67%
Pain: 3 people, 16.67%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 11.11%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 2 people, 11.11%
Arthropod Sting (arthropod bite): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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