Cortef and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Levaquin (levofloxacin). Common drug interactions include urinary tract infection among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Levaquin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Aug, 02, 2026

81 people who take Cortef and Levaquin together, and have interactions are studied.

What are the common drug interactions of Cortef and Levaquin, by gender? *:

female:

Urinary tract infection
Bacteraemia (presence of bacteria in the blood)
Device related infection
Diarrhoea
Injury
Vomiting
Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Asthma

male:

Neuropathy peripheral (surface nerve damage)
Plasma cell myeloma (cancer that begins in plasma cells)
Abdominal pain
Acute abdomen
Atrioventricular block second degree (heart block second degree)
Blood bilirubin increased
Blood chloride increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug level below therapeutic

What are the common drug interactions of Cortef and Levaquin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Blood bilirubin increased
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Vomiting
White blood cell count decreased

20-29:

Anxiety
Hereditary angioedema (recurrent episodes of severe swelling)
Back pain
Decreased appetite
Depression
Disturbance in attention
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oedema peripheral (superficial swelling)

30-39:

Acidosis (build-up of carbon dioxide in the blood)
Blood chloride increased
Ear infection
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Glomerulonephritis membranoproliferative (a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (gbm) thickening)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Post procedural complication
Renal tubular atrophy (wasting of kidney tubules)

40-49:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Alanine aminotransferase increased
Anaemia (lack of blood)
Analgesic drug level increased
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased

50-59:

Gout (uric acid crystals building up in the body)
Heart transplant rejection
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mycobacterium avium complex infection
Neck pain
Renal failure chronic (long lasting kidney dysfunction)
Renal mass (mass in kidney)
Seroma (a tumour like collection of serum in the tissues)
Abscess rupture (pus release from the point of abscess)
Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Bone fragmentation
Breast cancer recurrent
Candidiasis (candidiasis or thrush is a fungal infection)
Colitis (inflammation of colon)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Costochondritis (chest wall pain)
Depression
Device related infection

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 11 people, 13.58%
Nausea (feeling of having an urge to vomit): 10 people, 12.35%
Drowsiness: 8 people, 9.88%
Immunodeficiency Common Variable: 7 people, 8.64%
Foot Fracture: 6 people, 7.41%
Constipation: 6 people, 7.41%
Nausea And Vomiting: 5 people, 6.17%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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