Cortef and Nitrostat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Nitrostat (nitroglycerin). Common drug interactions include abdominal discomfort among females and device failure among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Nitrostat. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Nitrostat?

Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.



On Apr, 23, 2026

17 people who take Cortef and Nitrostat together, and have interactions are studied.

Cortef and Nitrostat drug interactions.

What are the common drug interactions of Cortef and Nitrostat, by gender? *:

female:

  1. Abdominal discomfort
  2. Alopecia (absence of hair from areas of the body)
  3. Anaemia (lack of blood)
  4. Anxiety
  5. Asthenia (weakness)
  6. Asthma
  7. Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
  8. Blood creatine phosphokinase increased
  9. Blood potassium decreased
  10. Bone pain

male:

  1. Device failure
  2. Bacterial test positive
  3. Death
  4. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  5. Haemorrhagic anaemia (anaemia due to excessive bleeding)
  6. Post procedural complication
  7. Propionibacterium test positive

What are the common drug interactions of Cortef and Nitrostat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Coma (state of unconsciousness lasting more than six hours)
  2. Fall
  3. Pneumonia
  4. Subdural haemorrhage (bleeding between the skull and the surface of the brain)
  5. Chronic kidney disease
  6. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Renal failure (kidney dysfunction)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Flushing (the warm, red condition of human skin)
  3. Blood creatine phosphokinase increased
  4. Blood potassium decreased
  5. Bone pain
  6. Chills (felling of cold)
  7. Colitis ulcerative (inflammation of colon with ulcer)
  8. Cough
  9. Diplopia (double vision)
  10. Dizziness

What are the existing conditions these people have? *

  1. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 8 people, 47.06%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 41.18%
  3. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 7 people, 41.18%
  4. Muscle Disorder (muscle disease): 4 people, 23.53%
  5. Diarrhea: 2 people, 11.76%
  6. Hypersensitivity: 2 people, 11.76%
  7. Oedema (fluid collection in tissue): 2 people, 11.76%
  8. Pain: 2 people, 11.76%
  9. Asthma: 2 people, 11.76%
  10. Stress And Anxiety: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Cortef and Nitrostat?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cortef and Nitrostat:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nitrostat:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nitrostat and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and nitroglycerin (the active ingredients of Cortef and Nitrostat, respectively), and Cortef and Nitrostat (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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