Cortef and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Spironolactone (spironolactone). Common drug interactions include fatigue among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Spironolactone. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

67 people who take Cortef and Spironolactone together, and have interactions are studied.

Cortef and Spironolactone drug interactions.

What are the common drug interactions of Cortef and Spironolactone, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Asthenia (weakness)
Sinusitis (inflammation of sinus)
Cough
Pneumonia
Dehydration (dryness resulting from the removal of water)
Fall
Pain
Dyspnoea (difficult or laboured respiration)

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cyst (a closed sac)
Oesophageal adenocarcinoma (a cancer tumour of an epithelium in oesophagus)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal neoplasm (cancer of the stomach)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Fall
Head injury
Hospitalisation

What are the common drug interactions of Cortef and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hospitalisation

10-19:

Fall
Head injury

20-29:

n/a

30-39:

Cough
Fatigue (feeling of tiredness)
Pain
Upper-airway cough syndrome
Nasopharyngitis (inflammation of the nasopharynx)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain

40-49:

Acute psychosis (period of mentally unstable behaviour)
Blood calcium decreased
Blood glucose decreased
Blood potassium decreased
Blood sodium decreased
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Delusion (a false belief or opinion)
Depressed level of consciousness
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Pain in extremity
Pain in jaw
Poor quality sleep
Restless legs syndrome (a powerful urge to move your legs)
Sinus disorder (disease of sinus)
Tinnitus (a ringing in the ears)
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal distension
Anxiety
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)

60+:

Headache (pain in head)
Sinusitis (inflammation of sinus)
Drug hypersensitivity
Thrombosis (formation of a blood clot inside a blood vessel)
Asthma
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Multiple allergies (allergy to multiple agents)
Cellulitis (infection under the skin)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Muscle tightness

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 14 people, 20.90%
Constipation: 8 people, 11.94%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.96%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 8.96%
Irritable Bowel Syndrome: 5 people, 7.46%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 5 people, 7.46%
Stress And Anxiety: 5 people, 7.46%
Sinusitis (inflammation of sinus): 5 people, 7.46%
Vaginal Infection: 5 people, 7.46%
Depression: 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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