Cortef and Tacrolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Tacrolimus (tacrolimus). Common drug interactions include abortion spontaneous among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Tacrolimus. It is created by eHealthMe based on reports of 7 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

On Apr, 29, 2026

7 people who take Cortef and Tacrolimus together, and have interactions are studied.

Cortef and Tacrolimus drug interactions.

What are the common drug interactions of Cortef and Tacrolimus, by gender? *:

female:

Abortion spontaneous (naturally occurring miscarriage)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Infusion site swelling
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Mass
Gastrointestinal fungal infection
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Intestinal ulcer

male:

Arthralgia (joint pain)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin ulcer
Erythema (redness of the skin)
Rash macular (small, flat red spots)
Joint range of motion decreased (disease of joint movement)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the common drug interactions of Cortef and Tacrolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gastrointestinal fungal infection
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Intestinal ulcer
Oral fungal infection
Rectal haemorrhage (bleeding from anus)

30-39:

n/a

40-49:

Abortion spontaneous (naturally occurring miscarriage)
Arthralgia (joint pain)
Pain in extremity
Peroneal nerve palsy
Rash
Skin disorder (skin disease)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin ulcer

50-59:

n/a

60+:

n/a

* Approximation only. Some reports may have incomplete information.

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