Cosopt and Adalat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Adalat (nifedipine). Common drug interactions include urosepsis among females and cerebral haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Adalat. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Adalat?

Adalat has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 20,940 Adalat users. Check the latest studies of Adalat.

On Jul, 18, 2026

31 people who take Cosopt and Adalat together, and have interactions are studied.

What are the common drug interactions of Cosopt and Adalat, by gender? *:

female:

Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Uterine cancer
Asthenia (weakness)
Constipation
Pain in extremity
Back pain
Chest pain
Diarrhoea
Dizziness
Gait disturbance

male:

Cerebral haemorrhage (bleeding within the brain)
Metastases to adrenals (cancer spreads to adrenal gland of kidney)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Constipation
Cough
Diarrhoea
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
General physical health deterioration (weak health status)
Headache (pain in head)

What are the common drug interactions of Cosopt and Adalat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood creatinine increased
Fatigue (feeling of tiredness)
Haemoglobin decreased
Haemorrhage (bleeding)
Headache (pain in head)
Induced labour (prematurely stimulating childbirth in a woman)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Renal impairment (severely reduced kidney function)
Renal tubular necrosis (death of kidney tubules)
Tremor (trembling or shaking movements in one or more parts of your body)

40-49:

Abdominal pain
Abscess jaw (tooth abscess or root abscess)
Actinic keratosis (skin disease due to sun exposure)
Aggression
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Colon gangrene (colon tissue dies)
Intestinal obstruction
Pleural effusion (water on the lungs)
Pneumonia
Conjunctival hyperaemia (congestion of conjunctival vessels)
Constipation
Dyspepsia (indigestion)
Erythema of eyelid (redness of the eyelid)
Growth of eyelashes

60+:

Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Carotid artery stenosis (narrowing of carotid artery)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chills (felling of cold)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 32.26%
High Blood Cholesterol: 3 people, 9.68%
Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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