Eszopiclone and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Eszopiclone (eszopiclone), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Vitamin C, and have Short-bowel syndrome.

The phase IV clinical study analyzes which people have Irritability when taking Eszopiclone. It is created by eHealthMe based on reports of 4,164 people who have side effects when taking Eszopiclone from the FDA, and is updated regularly.

What is Eszopiclone?

Eszopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 4,258 Eszopiclone users. Check the latest studies of Eszopiclone.

What is Irritability?

Irritability is found to be associated with 1,700 drugs and 2,458 conditions by eHealthMe. Check the latest studies of Irritability.

On Jul, 18, 2026

4,164 people reported to have side effects when taking Eszopiclone.
Among them, 23 people (0.55%) have Irritability.

Among these 23 people:

How long have people been on Eszopiclone when they have Irritability? *

What is the gender of people who have Irritability when taking Eszopiclone? *

female: 50 %
male: 50 %

What is the age of people who have Irritability when taking Eszopiclone? *

What are other drugs people take besides Eszopiclone? *

Vitamin C: 7 people, 30.43%
Vitamin D2: 6 people, 26.09%
Lunesta: 5 people, 21.74%
Tylenol: 5 people, 21.74%
Moxifloxacin: 4 people, 17.39%
Tamsulosin Hydrochloride: 4 people, 17.39%
Oxycodone Hydrochloride: 4 people, 17.39%
Ergocalciferol: 4 people, 17.39%
Potassium Acetate: 4 people, 17.39%
Hydroxychloroquine Sulfate: 4 people, 17.39%

What are other side effects people have besides Irritability? *

Stress And Anxiety: 8 people, 34.78%
Agitation (state of anxiety or nervous excitement): 6 people, 26.09%
Fatigue (feeling of tiredness): 5 people, 21.74%
Diarrhea: 5 people, 21.74%
Feeling Abnormal: 4 people, 17.39%
Delusion (a false belief or opinion): 4 people, 17.39%
Dehydration (dryness resulting from the removal of water): 4 people, 17.39%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 17.39%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 17.39%
Mood Swings (an extreme or rapid change in mood): 3 people, 13.04%

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 17.39%
Bipolar Disorder (mood disorder): 3 people, 13.04%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.70%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 8.70%
Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 4.35%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.35%
Renal Cell Carcinoma (a kidney cancer): 1 person, 4.35%
Parkinson's Disease: 1 person, 4.35%
Migraine (headache): 1 person, 4.35%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Eszopiclone and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eszopiclone:

Eszopiclone (4,258 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Eszopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,700 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,458 conditions)

Related publications that referenced our studies

Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .
Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Eszopiclone) and Eszopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.