Cosopt and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include atrial fibrillation among females and corneal perforation among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Isosorbide dinitrate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 12, 2026

16 people who take Cosopt and Isosorbide dinitrate together, and have interactions are studied.

Cosopt and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Cosopt and Isosorbide Dinitrate, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fall
Bradycardia (abnormally slow heart action)
Fatigue (feeling of tiredness)
Heart rate irregular
Lethargy (tiredness)
Wrist fracture
Mixed liver injury
Multiple injuries
Radius fracture

male:

Corneal perforation (small hole in a cornea)
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Heart rate decreased
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Rib fracture
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Cosopt and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Corneal perforation (small hole in a cornea)
Herpes ophthalmic (eye infection caused by herpes simplex virus (hsv))
Rib fracture

50-59:

Flushing (the warm, red condition of human skin)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fall
Heart rate decreased
Hip fracture
Mixed liver injury
Multiple injuries
Oedema peripheral (superficial swelling)
Osteomyelitis (infection of bone)
Pruritus (severe itching of the skin)
Radius fracture

What are the existing conditions these people have? *

Helicobacter Gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium): 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Cancer Pain: 2 people, 12.50%
Cystinosis (abnormal accumulation of the amino acid cystine): 2 people, 12.50%
Depression: 2 people, 12.50%
Diabetes: 2 people, 12.50%
Essential Thrombocythaemia (chronic blood cancer): 2 people, 12.50%
Haemorrhage (bleeding): 2 people, 12.50%
Acute Myocardial Infarction (acute heart attack): 2 people, 12.50%
Hyperchlorhydria (gastric acid levels are higher in stomach): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and Isosorbide dinitrate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously