Cosopt and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Profen (ibuprofen). Common drug interactions include diarrhoea among females and infection among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Profen. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Aug, 09, 2026

94 people who take Cosopt and Profen together, and have interactions are studied.

What are the common drug interactions of Cosopt and Profen, by gender? *:

female:

Diarrhoea
Hyperglycaemia (high blood sugar)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chest discomfort
Dehydration (dryness resulting from the removal of water)

male:

Infection
Dengue fever
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Chest pain
Confusional state
Constipation
Gait disturbance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Cosopt and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Perichondritis (inflammation of the perichondrium, a layer of connective tissue which surrounds cartilage)
Pericoronitis (inflammation of the gingiva surrounding the crown of a tooth)
Subcutaneous abscess
Swelling face
Bone loss
Ear neoplasm (tour in ear)
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage))
Eye swelling
Neoplasm of orbit (a tumour of cavity of eye that holds the globe)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dengue fever
Infection
Insomnia (sleeplessness)
Hypersensitivity
Memory impairment
Depression
Drug ineffective
General physical health deterioration (weak health status)
Hypotension (abnormally low blood pressure)
Influenza like illness

50-59:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dysarthria (speech disorder)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Headache (pain in head)
Insomnia (sleeplessness)

60+:

Anaemia (lack of blood)
General physical health deterioration (weak health status)
Hyperglycaemia (high blood sugar)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Constipation
Diarrhoea
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the existing conditions these people have? *

Fever: 8 people, 8.51%
High Blood Pressure: 7 people, 7.45%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 6.38%
Back Pain: 6 people, 6.38%
Angle Closure Glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity): 6 people, 6.38%
Stress And Anxiety: 5 people, 5.32%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 5.32%

* Approximation only. Some reports may have incomplete information.

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