Cosopt and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Promethazine (promethazine hydrochloride). Common drug interactions include asthenia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Promethazine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

On Jul, 13, 2026

18 people who take Cosopt and Promethazine together, and have interactions are studied.

Cosopt and Promethazine drug interactions.

What are the common drug interactions of Cosopt and Promethazine, by gender? *:

female:

Asthenia (weakness)
Atrophic vulvovaginitis (inflammation of the vulva)
Back disorder
Benign neoplasm of adrenal gland (benign (non-cancerous) tumours of the adrenal gland)
Blindness
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cataract (clouding of the lens inside the eye)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal injury (kidney injury)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Tooth injury
Tooth loss
Weight decreased
Bone pain
Dental caries
Depressed mood

What are the common drug interactions of Cosopt and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Diarrhoea haemorrhagic (bloody diarrhoea)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

30-39:

n/a

40-49:

n/a

50-59:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Confusional state
Constipation
Cough
Death
Decreased interest
Delusion (a false belief or opinion)
Depression

60+:

Fall
Neuropathy peripheral (surface nerve damage)
Cellulitis (infection under the skin)
Compression fracture (fracture due to pressure caused by injury)
Constipation
Cough
Device failure
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 27.78%
High Blood Pressure: 5 people, 27.78%
Pain: 5 people, 27.78%
Diabetes: 3 people, 16.67%
High Blood Cholesterol: 3 people, 16.67%
Depression: 3 people, 16.67%
Hypersensitivity: 2 people, 11.11%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 2 people, 11.11%
Herpes Virus Infection: 2 people, 11.11%
Urinary Retention (the inability to completely or partially empty the bladder): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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