Cosopt and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Vytorin (ezetimibe; simvastatin). Common drug interactions include bursitis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Vytorin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 09, 2026

35 people who take Cosopt and Vytorin together, and have interactions are studied.

What are the common drug interactions of Cosopt and Vytorin, by gender? *:

female:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Deformity (disfigurement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Ear pain
Exposed bone in jaw
Gait disturbance
General physical health deterioration (weak health status)

male:

Arthralgia (joint pain)
Chest pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Weight decreased
Abdominal abscess (collection of pus in abdomen)
Abdominal distension

What are the common drug interactions of Cosopt and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthropathy
Atrioventricular block first degree (heart block first degree)
Back pain
Blood creatinine increased
Blood potassium increased
Blood testosterone decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Brachial plexus injury (brachial plexus injuries, are caused by damage to those nerves network that conducts signals from the spinal cord)
Cerumen impaction
Chest pain

60+:

Chronic kidney disease
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 13 people, 37.14%
High Blood Pressure: 8 people, 22.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.29%
Diabetes: 5 people, 14.29%
Depression: 3 people, 8.57%
Urination - Excessive Volume: 2 people, 5.71%
Stress And Anxiety: 2 people, 5.71%
Sleep Disorder: 2 people, 5.71%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.71%
Dyslipidaemia (abnormal amount of lipids): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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