Cotrim d.s. and Pantoprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim d.s. (sulfamethoxazole; trimethoprim) and Pantoprazole (pantoprazole sodium). Common drug interactions include leukopenia among females and plasma cell myeloma among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim d.s. and Pantoprazole. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim d.s.?

Cotrim d.s. has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 274 Cotrim d.s. users. Check the latest studies of Cotrim d.s..

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,165 Pantoprazole users. Check the latest studies of Pantoprazole.

On Jul, 18, 2026

46 people who take Cotrim d.s. and Pantoprazole together, and have interactions are studied.

Cotrim d.s. and Pantoprazole drug interactions.

What are the common drug interactions of Cotrim D.S. and Pantoprazole, by gender? *:

female:

Leukopenia (less number of white blood cells in blood)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal vessel disorder (disease of kidney vessel)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal distension
Abdominal pain upper
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Anaemia (lack of blood)
Anastomotic complication (complication of surgical connection between two structures)

male:

Plasma cell myeloma (cancer that begins in plasma cells)
Thrombocytopenia (decrease of platelets in blood)
Device related infection
Diarrhoea
Fatigue (feeling of tiredness)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hypokalaemia (low potassium)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

What are the common drug interactions of Cotrim D.S. and Pantoprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Complications of transplanted kidney
Diarrhoea
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)
Intra-abdominal haematoma (intra-abdominal localized swelling filled with blood)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Renal tubular atrophy (wasting of kidney tubules)

30-39:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Hepatic steatosis (fatty liver disease)
Infection
Perforated ulcer
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Upper respiratory tract infection
Urinary tract infection

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Renal vessel disorder (disease of kidney vessel)
Urinary tract infection
Alanine aminotransferase increased
Aphthous ulcer (mouth ulcer)
Aspartate aminotransferase increased
Blood creatinine increased

50-59:

Staphylococcus test positive
Sternal fracture
Plasma cell myeloma (cancer that begins in plasma cells)
Device related infection
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Pneumonia
Chills (felling of cold)
Escherichia test positive
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

60+:

Renal failure (kidney dysfunction)
Leukopenia (less number of white blood cells in blood)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Abdominal pain upper
Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)
Asthenia (weakness)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Colitis (inflammation of colon)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 30.43%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 10.87%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.87%
Infection: 4 people, 8.70%
Herpes Zoster: 4 people, 8.70%
Diabetes: 4 people, 8.70%
Immunodeficiency Disorders: 3 people, 6.52%
High Blood Pressure: 3 people, 6.52%
High Blood Cholesterol: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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