Cotrim d.s. and Valcyte drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim d.s. (sulfamethoxazole; trimethoprim) and Valcyte (valganciclovir hydrochloride). Common drug interactions include ascites among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim d.s. and Valcyte. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim d.s.?

Cotrim d.s. has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 274 Cotrim d.s. users. Check the latest studies of Cotrim d.s..

What is Valcyte?

Valcyte has active ingredients of valganciclovir hydrochloride. It is often used in cmv - immunocompromised host. eHealthMe is studying from 6,409 Valcyte users. Check the latest studies of Valcyte.

On Aug, 10, 2026

12 people who take Cotrim d.s. and Valcyte together, and have interactions are studied.

Cotrim d.s. and Valcyte drug interactions.

What are the common drug interactions of Cotrim D.S. and Valcyte, by gender? *:

female:

Ascites (accumulation of fluid in the abdominal cavity)
Abdominal distension
Abdominal pain upper
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Blood lactate dehydrogenase increased
C-reactive protein increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Colitis (inflammation of colon)
Cough
Cytomegalovirus infection

male:

Diarrhoea
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Vomiting
Anaemia (lack of blood)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Complications of transplanted kidney
Cough
Cytomegalovirus infection

What are the common drug interactions of Cotrim D.S. and Valcyte, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Complications of transplanted kidney
Diarrhoea
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)
Intra-abdominal haematoma (intra-abdominal localized swelling filled with blood)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Renal tubular atrophy (wasting of kidney tubules)

30-39:

Immunosuppressant drug level decreased
Pyrexia (fever)

40-49:

Cytomegalovirus colitis (an inflammation of the colon from virus)
Drug ineffective
Drug resistance (reduction in effectiveness of a drug)
Leukopenia (less number of white blood cells in blood)

50-59:

Diarrhoea
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pleural effusion (water on the lungs)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Cytomegalovirus infection

60+:

Ascites (accumulation of fluid in the abdominal cavity)
Pneumonia
Cytomegalovirus infection
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Haemorrhagic disorder (bleeding disorder)

What are the existing conditions these people have? *

Cytomegalovirus Infection: 2 people, 16.67%
Immunodeficiency Disorders: 2 people, 16.67%
Urination - Painful: 1 person, 8.33%
Fever: 1 person, 8.33%
Cataract (clouding of the lens inside the eye): 1 person, 8.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 8.33%
Coughing Up Blood: 1 person, 8.33%
Diabetes: 1 person, 8.33%
Dyspnea (difficult or laboured breathing): 1 person, 8.33%
Enlarged Prostate: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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