Cotrim and Sprycel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Sprycel (dasatinib). Common drug interactions include pleural effusion among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Sprycel. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Sprycel?

Sprycel has active ingredients of dasatinib. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 29,788 Sprycel users. Check the latest studies of Sprycel.

On Jul, 14, 2026

20 people who take Cotrim and Sprycel together, and have interactions are studied.

What are the common drug interactions of Cotrim and Sprycel, by gender? *:

female:

Pleural effusion (water on the lungs)
Anaemia (lack of blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
White blood cell count decreased
Nausea (feeling of having an urge to vomit)
Abdominal pain
Blood pressure increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Platelet count decreased
Pleural effusion (water on the lungs)
Anaemia (lack of blood)
Aspartate aminotransferase increased
Asthenia (weakness)
Blast crisis in myelogenous leukaemia
Brain injury
Cerebral disorder (brain disease)
Completed suicide (act of taking one's own life)
Confusional state

What are the common drug interactions of Cotrim and Sprycel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Alanine aminotransferase increased
Altered state of consciousness (altered state of mind)
Aspartate aminotransferase increased
Bone marrow disorder
Coagulopathy (blood's ability to clot is impaired)
Eosinophil count increased
Hypocoagulable state (abnormality of blood coagulation that increases the risk of thrombosis)
Inflammation

10-19:

n/a

20-29:

Anaemia (lack of blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Interstitial lung disease
Neoplasm malignant (cancer tumour)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)
Pericardial effusion (fluid around the heart)
Platelet count decreased
Pleural effusion (water on the lungs)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Hepatic failure (liver failure)
Malignant neoplasm progression (cancer tumour came back)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Nausea (feeling of having an urge to vomit)
Pericardial effusion malignant (cancerous fluid around the heart)
Pneumonia fungal
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Rash

40-49:

Completed suicide (act of taking one's own life)
General physical health deterioration (weak health status)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Abdominal pain
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Vomiting
Aggression
Brain injury
Confusional state
Dementia (madness)
Dizziness
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

60+:

Platelet count decreased
Pleural effusion (water on the lungs)
Febrile neutropenia (fever with reduced white blood cells)
Gastritis (inflammation of stomach)
Generalised oedema (swelling all over the body)
Malignant neoplasm progression (cancer tumour came back)
Oedema peripheral (superficial swelling)
Oesophagitis (inflammation of oesophagus)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 55.00%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 7 people, 35.00%
Infection: 3 people, 15.00%
Pseudomembranous Colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon): 2 people, 10.00%
Gastric Ulcer (stomach ulcer): 2 people, 10.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 5.00%
Gout (uric acid crystals building up in the body): 1 person, 5.00%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 1 person, 5.00%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 5.00%
Adverse Drug Reaction: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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