Coumadin and Tarka drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coumadin (warfarin sodium) and Tarka (trandolapril; verapamil hydrochloride). Common drug interactions include anhedonia among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Coumadin and Tarka. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Tarka?

Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.

On Aug, 02, 2026

35 people who take Coumadin and Tarka together, and have interactions are studied.

What are the common drug interactions of Coumadin and Tarka, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Emotional distress
Fall
Fear
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Haemoglobinuria (the presence of free haemoglobin in the urine)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Dyspnoea (difficult or laboured respiration)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Anaemia (lack of blood)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Back pain
Colonic polyp (extra part of colon tissue grow in intestine)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

What are the common drug interactions of Coumadin and Tarka, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dermatitis allergic (inflammation of the skin due allergic reaction)
Diarrhoea
Dry mouth
Ear pain
Energy increased
Glossodynia (a burning or painful sensation in the tongue)
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)
Headache (pain in head)
Hypercoagulation (increased tendency for clotting of the blood)
Increased appetite

50-59:

Weight decreased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Rash
Swelling face
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Cardiac failure congestive
Diarrhoea
Skin ulcer

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Emotional distress
Injury
Nausea (feeling of having an urge to vomit)
Pain
Renal failure chronic (long lasting kidney dysfunction)
Stress

What are the existing conditions these people have? *

Diabetes: 4 people, 11.43%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 11.43%
Depression: 3 people, 8.57%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.57%
Rectal Cancer (cancer of rectum): 2 people, 5.71%
Insomnia (sleeplessness): 2 people, 5.71%
Anaemia (lack of blood): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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