Cozaar and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cozaar (losartan potassium) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include femur fracture among females and bone disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Cozaar and Cotrim. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 26, 2026

26 people who take Cozaar and Cotrim together, and have interactions are studied.

What are the common drug interactions of Cozaar and Cotrim, by gender? *:

female:

Femur fracture
Lower limb fracture
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Osteonecrosis of jaw (death of bone of jaw)
Pneumonia cryptococcal (pneumonia caused by cryptococcal infection)

male:

Bone disorder
Constipation
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Atrial tachycardia (rhythm disturbance that arises in the atria)
Atrioventricular block complete (heart block complete)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bradycardia (abnormally slow heart action)
Cardiac murmur (an heart sound in valve abnormality)
Chest pain

What are the common drug interactions of Cozaar and Cotrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

T-cell lymphoma (a blood cell cancer)
Tonsillitis (inflammation of tonsil)

20-29:

n/a

30-39:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)

40-49:

n/a

50-59:

Cellulitis (infection under the skin)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Decreased interest
Dehydration (dryness resulting from the removal of water)
Denervation atrophy (interruption of the nerve connection to an organ waste away)
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)

60+:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Constipation
Cough
Depression
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dizziness
Dry skin
Dysgeusia (disorder of the sense of taste)

What are the existing conditions these people have? *

High Blood Cholesterol: 13 people, 50.00%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 12 people, 46.15%
Multiple Myeloma (cancer of the plasma cells): 12 people, 46.15%
Mood Swings (an extreme or rapid change in mood): 12 people, 46.15%
Joint Pain: 12 people, 46.15%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 46.15%
Diarrhea: 12 people, 46.15%
Seasonal Allergy (allergic condition due to certain season): 6 people, 23.08%
Blood Triglycerides Decreased: 6 people, 23.08%
Osteoporosis (bones weak and more likely to break): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

Do you take Cozaar and Cotrim?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously