Cozaar and Protopic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cozaar (losartan potassium) and Protopic (tacrolimus). Common drug interactions include fluid overload among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Cozaar and Protopic. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

On Jul, 11, 2026

27 people who take Cozaar and Protopic together, and have interactions are studied.

What are the common drug interactions of Cozaar and Protopic, by gender? *:

female:

Fluid overload (too much fluid in the blood)
Gait disturbance
Alanine aminotransferase increased
Aldolase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Asthenia (weakness)
Back pain
Blood creatine phosphokinase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Diarrhoea
Abdominal pain
Anastomotic complication (complication of surgical connection between two structures)
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Aortic valve incompetence
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Asterixis (flapping tremor, or liver flap)

What are the common drug interactions of Cozaar and Protopic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Drug eruption (adverse drug reaction of the skin)
Hip arthroplasty
Pancreatitis (inflammation of pancreas)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

50-59:

Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Gallbladder disorder
Pancreatitis (inflammation of pancreas)
Weight decreased
Diarrhoea infectious (bacteria, viruses, and other germs can cause diarrhoea)

60+:

Pain
Aphasia (damage to the parts of the brain that control language)
Drug hypersensitivity
Drug ineffective
Eye infection
Gait disturbance
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hydronephrosis (water inside the kidney)
Hypoacusis (loss of hearing)
Ileal stenosis (obstruction in the ileal)

What are the existing conditions these people have? *

Neuropathy Peripheral (surface nerve damage): 4 people, 14.81%
Skin Irritation: 3 people, 11.11%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 11.11%
Pain: 3 people, 11.11%
Nausea (feeling of having an urge to vomit): 3 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 11.11%
Stress And Anxiety: 2 people, 7.41%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 7.41%
Immunodeficiency Common Variable: 2 people, 7.41%
Fatigue (feeling of tiredness): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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