Cozaar and Sublimaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cozaar (losartan potassium) and Sublimaze (fentanyl citrate). Common drug interactions include diverticulitis among females and blood bilirubin increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cozaar and Sublimaze. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

On Aug, 04, 2026

22 people who take Cozaar and Sublimaze together, and have interactions are studied.

What are the common drug interactions of Cozaar and Sublimaze, by gender? *:

female:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Acute respiratory failure
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute hepatic failure
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac tamponade (fluid accumulates in heart covering)
Cardiogenic shock (inadequate circulation of blood)
Chronic kidney disease
Disseminated intravascular coagulation (systemic activation of blood coagulation)

male:

Blood bilirubin increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hypokalaemia (low potassium)
Leukocytosis (increased white blood cells)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Neutropenia (an abnormally low number of neutrophils)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Urinary tract infection
Vomiting

What are the common drug interactions of Cozaar and Sublimaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Leukocytosis (increased white blood cells)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Cellulitis (infection under the skin)
Groin infection (infection in groin)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Asthenia (weakness)
Bone density decreased
Death
Emotional distress
Pain
Tooth fracture
Tooth loss

60+:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Sepsis (a severe blood infection that can lead to organ failure and death)
Aspartate aminotransferase increased
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood alkaline phosphatase increased
Cardiac tamponade (fluid accumulates in heart covering)
Cardiogenic shock (inadequate circulation of blood)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

What are the existing conditions these people have? *

Pain: 8 people, 36.36%
Infection: 5 people, 22.73%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 22.73%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 22.73%
Fever: 5 people, 22.73%
Insomnia (sleeplessness): 4 people, 18.18%
Depression: 4 people, 18.18%
Hypokalemia (low potassium): 4 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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