Loraz and Ofirmev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Ofirmev (acetaminophen). Common drug interactions include disseminated intravascular coagulation among females and tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Ofirmev. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

What is Ofirmev?

Ofirmev has active ingredients of acetaminophen. eHealthMe is studying from 817 Ofirmev users. Check the latest studies of Ofirmev.

On Aug, 04, 2026

30 people who take Loraz and Ofirmev together, and have interactions are studied.

What are the common drug interactions of Loraz and Ofirmev, by gender? *:

female:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aspartate aminotransferase increased
Blood bilirubin increased
Ankle fracture
Bone density decreased
Bone loss
Colitis (inflammation of colon)
Emotional distress
Enterocutaneous fistula

male:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Coagulopathy (blood's ability to clot is impaired)
Ammonia increased
Apnoea (suspension of external breathing)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Confusional state
Cough

What are the common drug interactions of Loraz and Ofirmev, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased
Blood chloride increased

2-9:

n/a

10-19:

Abdominal pain
Anion gap increased
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood bilirubin increased
Blood calcium decreased
Blood chloride increased
Blood creatinine increased
Blood glucose increased
Blood lactate dehydrogenase increased

20-29:

Death

30-39:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Blood creatine phosphokinase increased
Coma (state of unconsciousness lasting more than six hours)
Hepatitis (inflammation of the liver)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hyperthermia (body temperature greatly above normal)
Hypotension (abnormally low blood pressure)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

40-49:

Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aspartate aminotransferase increased
Breast cancer
Compulsive shopping
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Panic disorder

50-59:

Aspartate aminotransferase increased
Blood bilirubin increased
Encephalopathy (functioning of the brain is affected by some agent or condition)
Pneumonia
Alanine aminotransferase increased
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac arrest
Heparin-induced thrombocytopenia
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Pneumonia bacterial (pneumonia associated with bacterial infection)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Enterocutaneous fistula
Factor viii inhibition (suppression of factor viii)
Intestinal obstruction
Intestinal perforation (complete penetration of the wall of the intestine)
Pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Osteonecrosis (death of bone)
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 16.67%
Fever: 3 people, 10.00%
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 2 people, 6.67%
Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 2 people, 6.67%
Sedation: 2 people, 6.67%
Pneumonia: 2 people, 6.67%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 2 people, 6.67%
Hiv Infection: 2 people, 6.67%
High Blood Pressure: 2 people, 6.67%
Gait Disturbance: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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