Creon and Ms contin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Ms contin (morphine sulfate). Common drug interactions include decreased appetite among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Ms contin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Ms contin?

Ms contin has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 69,289 Ms contin users. Check the latest studies of Ms contin.

On Jul, 05, 2026

74 people who take Creon and Ms contin together, and have interactions are studied.

What are the common drug interactions of Creon and Ms Contin, by gender? *:

female:

Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abortion spontaneous (naturally occurring miscarriage)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back disorder
Cardiac murmur (an heart sound in valve abnormality)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

male:

Diarrhoea
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cellulitis (infection under the skin)
Cholecystitis (infection of gallbladder)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Depressed level of consciousness
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug dependence

What are the common drug interactions of Creon and Ms Contin, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

n/a

10-19:

Coagulopathy (blood's ability to clot is impaired)
Multi-organ failure (multisystem organ failure)
Neurological symptom (symptoms of nervous system disease)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Respiratory failure (inadequate gas exchange by the respiratory system)

20-29:

n/a

30-39:

Infection
Pneumonia
Death

40-49:

Anxiety
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cellulitis (infection under the skin)
Cholecystitis (infection of gallbladder)
Confusional state
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed level of consciousness
Drug dependence
Drug ineffective
Drug tolerance increased

50-59:

Decreased appetite
Diarrhoea
Anorexia nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Coma (state of unconsciousness lasting more than six hours)
Faeces discoloured
Faeces hard
Hepatic steatosis (fatty liver disease)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

60+:

Abdominal pain
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Herpes virus infection
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Large intestinal haemorrhage (bleeding in large intestine)
Liver transplant rejection (failure of liver transplant)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 11 people, 14.86%
Breakthrough Pain: 10 people, 13.51%
Constipation: 10 people, 13.51%
Pancreatic Carcinoma (pancreatic cancer): 10 people, 13.51%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.81%
Stress And Anxiety: 7 people, 9.46%
Depression: 7 people, 9.46%
Abdominal Pain: 7 people, 9.46%
Neuralgia (pain in one or more nerves): 6 people, 8.11%
Sleep Disorder: 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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