Creon and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Soliris (eculizumab). Common drug interactions include pain in extremity among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Soliris. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Aug, 04, 2026

31 people who take Creon and Soliris together, and have interactions are studied.

What are the common drug interactions of Creon and Soliris, by gender? *:

female:

Pain in extremity
Pyrexia (fever)
Rash
Urine abnormality
Vasculitis (inflammation of a blood vessel or blood vessels)
Dysphagia (a condition in which swallowing is difficult or painful)
Hospitalisation
Apnoea (suspension of external breathing)
Biliary dilatation
Blood alkaline phosphatase increased

male:

Asthenia (weakness)
Urinary tract infection
Peptic ulcer
Thrombosis (formation of a blood clot inside a blood vessel)
Underweight
Vomiting
Body temperature increased
Colitis (inflammation of colon)
Heart rate increased
Hospitalisation

What are the common drug interactions of Creon and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alopecia (absence of hair from areas of the body)

10-19:

n/a

20-29:

n/a

30-39:

Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Ulna fracture (fracture inside bone)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Dysphagia (a condition in which swallowing is difficult or painful)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hemiparesis (weakness on one side of the body)

40-49:

Dry mouth
Hypertension (high blood pressure)
Loss of consciousness
Rash erythematous (redness of the skin)
Renal failure acute (rapid kidney dysfunction)
Small intestinal obstruction (blockage in small intestine)
Pain
Asthenia (weakness)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

50-59:

Delirium (wild excitement)
Psychotic disorder

60+:

Fatigue (feeling of tiredness)
Contusion (a type of hematoma of tissue in which capillaries)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Confusional state
Dysuria (painful or difficult urination)
Enterococcal infection
Haemoglobin decreased
Meningitis cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pancreatic cyst
Paraspinal abscess

What are the existing conditions these people have? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 14 people, 45.16%
Pain: 11 people, 35.48%
High Blood Pressure: 9 people, 29.03%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 7 people, 22.58%
Indigestion: 6 people, 19.35%
Purpura (purplish discoloration of the skin): 5 people, 16.13%
Osteoporosis (bones weak and more likely to break): 5 people, 16.13%
Insomnia (sleeplessness): 5 people, 16.13%
Nausea (feeling of having an urge to vomit): 3 people, 9.68%
Hypolipidaemia (an abnormally high concentration of fats or lipids in the blood): 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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