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Creon and Tagamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Tagamet (cimetidine). Common drug interactions include peripheral swelling among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Tagamet. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Tagamet?

Tagamet has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,011 Tagamet users. Check the latest studies of Tagamet.

On Aug, 07, 2026

12 people who take Creon and Tagamet together, and have interactions are studied.

Creon and Tagamet drug interactions.

What are the common drug interactions of Creon and Tagamet, by gender? *:

female:

  1. Peripheral swelling
  2. Spinal compression fracture (fracture due to spinal compression on bone)
  3. Chronic kidney disease
  4. Arthralgia (joint pain)
  5. Constipation
  6. Joint swelling

male:

  1. Anaemia (lack of blood)
  2. Chronic kidney disease
  3. Decreased appetite
  4. Full blood count decreased
  5. Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
  6. Weight decreased

What are the common drug interactions of Creon and Tagamet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Spinal compression fracture (fracture due to spinal compression on bone)

60+:

  1. Chronic kidney disease
  2. Anaemia (lack of blood)
  3. Arthralgia (joint pain)
  4. Constipation
  5. Decreased appetite
  6. Joint swelling
  7. Peripheral swelling

What are the existing conditions these people have? *

  1. Indigestion: 6 people, 50.00%
  2. High Blood Pressure: 6 people, 50.00%
  3. Chondrocalcinosis (crystal deposition disease): 5 people, 41.67%
  4. Multiple Myeloma (cancer of the plasma cells): 2 people, 16.67%
  5. Gastritis (inflammation of stomach): 2 people, 16.67%
  6. Carcinoid Tumor: 2 people, 16.67%
  7. Diabetes: 1 person, 8.33%
  8. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and Tagamet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Creon and Tagamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Creon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tagamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Creon and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tagamet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on pancrelipase (amylase;lipase;protease) and cimetidine (the active ingredients of Creon and Tagamet, respectively), and Creon and Tagamet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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